Virtuoso Epigenomics Platform
Virtuoso Epigenomics Platform
Empowering oncology drug discovery and development by offering dynamic insights into drug response and resistance.
Virtuoso is a research use only (RUO) platform that provides insights into active biological processes using whole genome epigenomic and genomic features revealed by a novel laboratory workflow and combined using a machine learning algorithm.
Workflow
The Virtuoso workflow is outlined in Figure 1. Whole blood is drawn from the subject using a standard phlebotomy procedure. Cell-free DNA (cfDNA) is then isolated from blood plasma. The cfDNA enters a whole genome sequencing workflow, including an innovative 5hmC-DNA enrichment process. The test directly measures active and relevant biological events by evaluating 5hmC-DNA profiles, copy number variations (CNVs), and cfDNA fragment sizes. A proprietary machine learning algorithm uses these features to identify relevant genomic features. Measuring active disease biology empowers oncology drug discovery and development by offering dynamic insights into drug response and resistance.
Virtuoso is for research use only. Not for use in diagnostic procedures.
Target
Engagement
Assess levels of drug target activity for patient selection or target engagement assessment
Longitudinal Monitoring of Therapy Response
Virtuoso analysis of cfDNA from blood provides consistent, reliable data across multiple timepoints, enhancing the ability to analyze therapeutic signatures of response throughout a study.
Understanding Mechanisms of Action, Response & Resistance
Virtuoso uncovers the biological underpinnings of drug response by analyzing epigenomic and genomic data, applicable from phase I-IV.
Subject
Stratification
Virtuoso generates DNA epigenomic profiles to stratify subjects based on unique biological markers and ctDNA quantification.
Learn More
Traditional drug development processes are challenged by limited tissue availability and lack of tools that can capture tumor evolution and biology that is driven by non-genetic mechanisms. The Virtuoso Epigenomics Platform is a groundbreaking whole genome sequencing and 5hmC enrichment solution designed to revolutionize translational research by revealing active disease biology to empower drug discovery and development.
Speak With One Of Our Experts
Speak with our expert scientific staff and learn how Virtuoso can help your drug development program.
Gulfem Guler, PhD
Vice President, Translational Research, Head of Biopharma Development
ClearNote Health
Important information
Virtuoso is for research use only. Not for use in diagnostic procedures.